HOUTTUYNIA CORDATA EXOSOMES – A next-generation, high-tech biomimetic ingredient derived from the cells of the medicinal plant Houttuynia cordata using the patented Korean J2K METAexosome technology. It is a concentrate of extracellular vesicles of endosomal origin (exosomes) containing 1.11 × 10⁸ active particles per milliliter of raw material. The mean vesicle size is 264.3 nm, with a dominant modal peak at 142.7 nm. The ultra-small particle size and the presence of a natural lipid envelope (lipid bilayer) provide a membrane-fusion effect, allowing the exosomes to integrate into recipient cells and deliver their biologically active cargo (proteins, lipids, RNA, phytocomponents) directly into the cell.

Houttuynia cordata exosomes have a multifunctional effect on sensitive and damaged skin:

1) Anti-inflammatory effect and relief of neurogenic inflammation. The component provides marked relief of inflammatory processes thanks to a high content of native soothing bioflavonoids — quercitrin and isoquercitrin. These rapidly reduce vascular stress, relieving itching, edema and diffuse redness (erythema).

2) Intensive soothing and barrier repair. Thanks to the high lipid concentration in the plant-derived vesicle membrane and the potent calming properties of the plant itself, the component demonstrates a pronounced anti-allergic action. It is ideally suited for treating dry, reactive and hypersensitive skin.

3) Antibacterial control and cell protection. Houttuynia extract shows distinct antibacterial and antiviral activity, inhibiting the growth of harmful bacteria on the surface of the epidermis. This helps prevent the damage and premature aging of skin cells provoked by pathogen toxins.

4) Deep hydration and antioxidant protection. The native polysaccharides contained in Houttuynia extract actively saturate the skin with moisture and lock it in. At the same time, the component has powerful antioxidant properties and a marked ability to reduce cell damage caused by ultraviolet (UV) radiation.

NIACINAMIDE (vitamin B3) – A multifunctional dermatological component whose action targets reduced inflammation, barrier strengthening and regulation of sebum secretion. It improves microcirculation, reinforces the lipid barrier and helps restore normal skin immunity.

Niacinamide is a precursor of nicotinamide adenine dinucleotide (NAD⁺) and NADP⁺, key coenzymes in cellular metabolism that participate in redox reactions and maintain the cell’s energy balance (glycolysis, the Krebs cycle, oxidative phosphorylation). By raising NADPH levels, niacinamide enhances the activity of the cell’s antioxidant systems (glutathione, thiomedoxin), protecting the skin from photodamage and premature aging. Niacinamide suppresses the activity of nuclear factor κB (NF-κB), which regulates the expression of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), thereby reducing inflammation and preventing tissue damage. In addition, niacinamide lowers the activity of the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT), a hormone that stimulates sebum production. This helps control skin oiliness and reduce breakouts. Niacinamide inhibits the transfer of melanosomes from melanocytes to keratinocytes, thereby reducing hyperpigmentation and brightening the skin. It also increases the expression of genes encoding procollagen-1 and the enzymes involved in its maturation, helping to reduce wrinkles and improve skin elasticity.

COTTON (GOSSYPIUM HERBACEUM) SEED EXTRACT – The extract’s efficacy is based on a high concentration of essential polyunsaturated fatty acids, phytosterols, vitamin E (tocopherols) and oligosaccharides. The extract is rich in linoleic acid, an integral part of type-1 ceramides that form the lipid barrier of the epidermis. It is clinically proven that a deficiency of linoleic acid leads to transepidermal water loss, flaking and acute reactivity. Incorporating cotton extract makes it possible to physiologically reconstruct the skin’s damaged protective layer.

Cotton contains a high concentration of sitosterol and campesterol. These plant molecules are structurally similar to the cholesterol of our skin. They have a pronounced anti-inflammatory and soothing action, stabilize cell membranes and reduce the activity of inflammatory mediators. The specific carbohydrates contained in the seeds act as natural osmolytes and prebiotics, retaining water molecules at the cell surface and supporting the stability of the epidermal microbiome. The native tocopherols in the extract neutralize free radicals, protecting cell membranes from oxidative stress. The component helps reduce capillary permeability, contributing to a reduction in congestion and mild edema that arise in inflammatory states.

Clinical studies confirm that cotton seed extract effectively blocks the cascade of reactions triggered by exogenous factors (temperature fluctuations, surfactants, PEGs, dry air). It rapidly relieves subjective sensations of discomfort — itching, burning and the feeling of tightness characteristic of reactive and rosacea-prone skin.

HYALURONIC ACID – Its high molecular weight of 1.6 million Da restores physiological homeostasis in the intercellular matrix, helping to activate the metabolism of skin cells. It restores not only the physiological concentration but also the fraction of large HA molecules, which declines with skin aging due to increased hyaluronidase concentration in the tissues. Normal homeostasis for fibroblasts triggers the synthesis of their own HA and other intercellular components.

HYDROLYZED RED ALGAE EXTRACT – A biotechnological active obtained through enzymatic hydrolysis of the cells of red algae of the Rhodophyta family. The hydrolysis process breaks the large polysaccharide chains down into low-molecular-weight oligosaccharides, amino acids and biomimetic peptides, giving them unprecedented bioavailability and the ability to easily cross the epidermal barrier. In modern dermocosmeceuticals, this component is recognized as a powerful osmolyte, angioprotector and eco-regulator that is indispensable in treating reactive, hypersensitive skin as well as skin showing signs of couperose, rosacea and persistent erythema.

Red algae extract is distinguished by a high content of sulfated galactans (carrageenans) and fucoidans. It is clinically proven that these molecules can block the cascade of neurogenic inflammation by suppressing the synthesis of key pro-inflammatory mediators and interleukins, which leads to an immediate reduction in the skin’s reactivity index and relief of itching, burning and the subjective sensation of heat.

The extract is of particular value for skin with a damaged microcapillary network, as it exhibits pronounced anti-edematous and vasoprotective activity: it strengthens the basement membranes of blood vessels, reduces capillary permeability and stabilizes microcirculation, making it possible to noticeably reduce manifestations of diffuse erythema (redness) and congestion while preventing the progression of couperose.

Alongside vascular control, the red algae hydrolysate acts as an effective marine prebiotic that harmoniously supports the vitality of the skin’s own microbiome. Its oligosaccharides serve as a nutrient substrate for the “friendly” microflora of the epidermis, optimizing its balance. This creates a favorable and stable ecological environment on the skin surface, radically boosting its local immunity, strengthening the protective mantle and making the skin less vulnerable to external triggers. At the same time, the component provides gentle antibacterial control, inhibiting the proliferation of those opportunistic bacterial strains that provoke acne and inflammatory lesions.

In addition, the extract activates powerful osmotic protection of cells: as a natural source of minerals (magnesium, potassium, calcium, silicon) and amino acids, it optimizes the water-salt balance in the epidermis and prevents transepidermal water loss.

BIOMIMETIC AMINO ACID COMPLEX (Arginine, Lysine HCl, Leucine, Threonine, Isoleucine, Proline) – A balanced complex of physiological amino acids (both essential and non-essential) for regeneration and molecular remodeling of the dermis. It fully replicates the amino acid profile of human structural proteins and promotes rapid repair of damaged tissue, which is critically important for skin in a state of acute stress, post-injection damage or chronic vasomotor disorders.

The amino acid complex can be incorporated instantly into the cellular metabolism of fibroblasts, bypassing the complex cascades of protein breakdown. Thanks to the presence of proline and lysine, the process of epithelialization and healing of microtraumas is significantly accelerated, the dermal scaffold is strengthened and skin density is restored “from within.” At the same time, the branched-chain essential amino acids (leucine and isoleucine), together with threonine, activate intracellular signaling pathways that stimulate cell division and the natural renewal of the epidermis.

It is clinically proven that saturating the dermis with this amino acid profile makes it possible to radically reduce transepidermal water loss (TEWL) and restore the integrity of the damaged epidermal barrier. The arginine in the complex additionally acts as a regulator of local microcirculation and tissue perfusion, improving cellular trophism without provoking vasodilation or congestive erythema. The synergistic action of the entire amino acid block results in an immediate increase in the skin’s resistance to external irritants, the elimination of chronic flaking and dryness, and a significant reduction in the recovery period after invasive cosmetic procedures.

INCI: Aqua / Water, Sodium Chloride, Niacinamide, Panthenol, Glycerin, Maris Aqua, Gossypium Herbaceum Seed Extract, Sodium Hyaluronate, Propanediol, Phenethyl Alcohol, Citric Acid, Hydrolyzed Rhodophyceae Extract, Caprylyl Glycol, Arginine, Lysine Hcl, Leucine, Sodium Hydroxide, Threonine, Isoleucine, Ethylhexylglycerin, Houttuynia Cordata Extract, Proline

Bij fractionele mesotherapie (met Dermapen) als kuur van 4–6 behandelingen met een interval van 14–28 dagen; bij toestelbehandelingen zoals elektroporatie en HydraFacial; en ook als booster-serum onder een alginaatmasker.